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- *******************************************
- * Glycosyl hydrolases family 16 signature *
- *******************************************
-
- It has been shown [1] that the following glycosyl hydrolases can be, on the
- basis of sequence similarities, classified into a single family:
-
- - Bacterial beta-1,3-1,4-glucanases (EC 3.2.1.73) (lichenases), mainly from
- Bacillus but also from Clostridium thermocellum (gene licB) and from
- Fibrobacter succinogenes.
- - Bacillus criculans beta-1,3-glucanase A1 (EC 3.2.1.39) (gene glcA).
- - Lamarinase (EC 3.2.1.6) from Clostridium thermocellum (gene lam1).
-
- Two closely clustered conserved glutamate have been shown [2], in Bacillus
- licheniformis lichenase, to be involved in the catalytic activity. We use the
- regions that contains these residues as a signature pattern.
-
- -Consensus pattern: E-[LIV]-D-[LIV]-x(0,1)-E-x(2)-G-[KRN]-x-[PST]
- [The two E's are active site residues]
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
-
- -Expert(s) to contact by email: Henrissat B.
- bernie@cermav.grenet.fr
-
- -Last update: June 1994 / First entry.
-
- [ 1] Henrissat B.
- Biochem. J. 280:309-316(1991).
- [ 2] Juncosa M., Pons J., Dot T., Querol E., Planas A.
- J. Biol. Chem. 269:14530-14535(1994).
-